GLP‑1
weight loss
you can actually
see working.
Signos+ is the only program that pairs clinician-prescribed GLP‑1 medication with an FDA-cleared CGM and app, so you lose the weight, understand why, and know how to keep it off. All for the same price as medication alone.
- Personalized GLP‑1 treatment plan
- Signos glucose monitoring system (CGM & app)
- Free, rapid shipping to your door
GLP‑1 medicates.
Signos educates.
Medication alone suppresses appetite. It doesn’t teach you what spikes your glucose, what drains your energy, or what habits keep the weight off when you stop. Signos+ is the first and only program that pairs GLP‑1 medication with a CGM and app, so you can succeed.
The fastest proven path to weight loss
GLP‑1 medications like semaglutide and tirzepatide suppress appetite and slow digestion to drive significant, clinically proven weight loss. A Signos clinician prescribes the right one for your body.
Real-time data your scale can't show you
A CGM is a small wearable sensor that tracks your blood sugar 24/7 with no finger pricks. It reveals exactly how your body responds to food, sleep, and movement, so you can see what's driving your weight in real time.
Why stabilizing glucose is the missing piece
Blood sugar spikes trigger insulin, your body's primary fat-storage signal. When glucose is unstable, cravings spike and weight returns after medication stops. CGM data builds the habits that change that.
87% report success in their first month.1
“GLP‑1 gave me a head start. Signos gave me control. The CGM helped me understand my metabolism in a way I never could before — and that’s what made the weight loss stick.”
Alexandra C. · Signos customer
Your glucose tells the story
your scale can’t.
Same person. Same meal. Two days apart. See what your body does differently.
Tue · 12:00p
Skipped breakfast. The pita went first.
Two hours above range. Fat-storage mode.
Thu · 12:00p
Same lunch. This time, protein first.3
Steady afternoon. Progress toward weight goals.
Try Signos+ to see your difference
Take the 2-minute quiz and a clinician will tailor your GLP‑1 plan.
Stabilize glucose.
Optimize your weight.
More than just data —
direction.
Other programs give you a pill and a generic meal guide. Signos shows you your metabolic patterns, identifies your personal triggers, and tells you exactly what to change — based on your data, not a template.
Breakfast timing
Eating before 8am keeps your glucose 23% more stable through lunch.
Post-lunch spikes
Rice without protein spikes you 40+ mg/dL. Adding chicken cuts it in half.
15-min walks
Post-meal walks reduced your average spike by 18% this month.
Glucose stability ↑ 12%
Your time-in-range improved from 74% to 86% since starting.
Medication gets you there.Glucose data keeps you there.
GLP‑1 gets the weight off. But without understanding your own metabolic patterns, most people regain much of the lost weight within a year. Signos glucose data changes that trajectory.4
Clinician-guided
medical weight loss.
Whether you’re new to GLP‑1s or continuing your journey with Signos, you’ll receive a personalized treatment plan from a licensed clinician.
Take a 5-minute quiz
Answer a few health questions to find the right plan and formula for your goals and lifestyle.
Clinician reviews
A licensed provider reviews your profile and approves the GLP‑1 treatment plan to accompany the Signos system.
Kit arrives
GLP‑1 medication + the Signos system are shipped directly to your home. Ongoing support is provided by licensed providers.
Real members. Real data.
Real results.
What happens when you pair GLP‑1 with real-time metabolic insight.5
“For the first time, I feel like I understand my body. The GLP‑1 helped me begin, but Signos showed me how to keep going — and that’s what made this feel different from every other attempt.”
Julia K.
Signos customer
“None of the GLP‑1 providers told me what was going to happen once I reached my goal weight. What was life after GLP‑1s. That’s what makes Signos a game changer — I know I’ll be able to keep the weight off without the medication.”
Max S.
Signos customer
“Other programs just sent me pills. Signos taught me that a 10-minute walk after dinner does more for my glucose than any supplement I’ve tried.”
Natalie M.
Signos customer
A program built
around you.
Every plan includes the complete Signos glucose monitoring system and app access,
GLP‑1 medication and supplies, and clinician-guided support for 6 months.
Signos Glucose Monitoring System
FDA-cleared wearable device + Signos App that delivers real-time data directly from your body. Optimize the path to your weight goal with small lifestyle changes for lasting results.
- Wearable device
- 4 CGM sensors
- Actionable prompts around meals, movement, and sleep
- Daily and weekly metabolic scores
- Registered dietician support
Clinician-guided GLP‑1 Treatment
Compounded Tirzepatide and Semaglutide + clinician-guided care. Reduce the biological barriers to weight loss by reducing hunger signals and slowing digestion to feel fuller, longer.
- Personalized, clinician-guided treatment plans
- Medication and supplies
- Injectable treatment options: Tirzepatide and Semaglutide
- Initial medical evaluation and regular check-ins with licensed providers
Take the 2-minute quiz and a clinician will tailor your GLP‑1 plan.
What to know before you start.
Signos+ is the only program that pairs clinician-prescribed GLP-1 medication with an FDA-cleared continuous glucose monitor and AI-powered app — so you can lose the weight, understand why, and know how to keep it off, all for the same price as medication alone. Your glucose data is sent directly to the app and combined with hundreds of millions of data points to predict responses to food and movement, track trends, log meals and doses, track your weight, see how your medication is actually working, and access science-backed guidance to build sustainable, glucose-stable habits. GLP-1 medications and clinical care come from licensed clinicians through our partner OpenLoop Health. You can also sync with Apple Health, Google Health Connect, smartwatches, and smart scales for a more complete view of your health.
Compounded Tirzepatide and Semaglutide along with clinician-guided care throughout your subscription. Your prescribing clinician determines the right medication and dose during your medical intake. All Signos+ medications are compounded; compounded GLP-1s are not FDA-approved.
When used consistently, CGMs (also known as biosensors) can support healthy, sustainable weight management by helping you understand how your body responds to food, exercise, and daily habits in real time.
Signos+ is available in 49 U.S. states and the District of Columbia. We’re not currently able to serve people in Louisiana due to state restrictions on compounded medications. If you live in AR, DC, DE, KS, MS, NM, RI, or WV, you’ll be asked to complete a video visit with a licensed clinician as part of your intake. General age eligibility is 18–74 (Nebraska requires 19+). The intake will confirm your eligibility based on your state.
It depends on your HSA/FSA provider. Coverage varies, so check with your provider to confirm whether GLP-1 programs like Signos+ are eligible. Please note: Signos is not responsible for reimbursement, and the cancellation policy and terms still apply, even if your provider does not approve coverage or reimbursement.
Do more than lose weight.
Learn how to keep it off.
GLP‑1 + Signos starting at $199/mo. Clinician-reviewed. Delivered to your door.
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Copyright © 2026 Signos Inc.
Signos indications: The Signos Glucose Monitoring System is an over-the-counter (OTC) mobile device application that receives data from an integrated Continuous Glucose Monitor (iCGM) sensor and is intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Signos Glucose Monitoring System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Signos Glucose Monitoring System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursions. This information may be useful in helping users to maintain a healthy weight.
The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
See user guide for important warnings and precautions.
STELO IMPORTANT INFORMATION: Consult your healthcare provider before making any medication adjustments based on your sensor readings and do not take any other medical action based on your sensor readings without consulting your healthcare provider. Do not use if you have problematic hypoglycemia. Failure to use Stelo and its components according to the instructions for use provided and to properly consider all indications, contraindications, warnings, and cautions in those instructions for use may result in you missing a severe hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose) occurrence. If your sensor readings are not consistent with your symptoms, a blood glucose meter may be an option as needed and consult your healthcare provider. Seek medical advice and attention when appropriate, including before making any medication adjustments and/or for any medical emergency.
STELO INDICATIONS FOR USE: The Stelo Glucose Biosensor System is an over-the-counter (OTC) integrated Continuous Glucose Monitor (iCGM) intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Stelo Glucose Biosensor System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Stelo Glucose Biosensor System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursion. The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
OPENLOOP CLINICAL AND PHARMACEUTICAL SERVICES:
Signos is a technology platform and wellness program provider. With the exception of registered dieticians, Signos does not employ licensed health care professionals to practice medicine, does not diagnose, treat, cure, or prevent any disease or medical condition, and does not provide medical advice. You should always consult your own health care professional for diagnosis, treatment, and care regarding any medical condition or health concern. Clinical services accessible through the Signos platform are provided solely by OpenLoop Health and other independent networks of U.S.-licensed clinicians, who exercise their own independent medical judgment to determine eligibility for GLP‑1 treatment based on medical history and assessment responses. These independent providers retain full discretion to prescribe or decline compounded GLP‑1 medications. Signos does not direct, control, or influence any clinical decision made by these providers, and no provider-patient relationship is created between you and Signos.
Compounded medications that may be made available in connection with the Signos program are produced in FDA-registered facilities, but are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. Signos does not manufacture, compound, dispense, or distribute any medications. Signos partners with certified U.S. pharmacies to help facilitate access to these medications, but Signos makes no representations or warranties regarding the safety, efficacy, suitability, or quality of any compounded medication. Product appearance may differ from website images.
Medication costs are included in the Signos program; however, inclusion of medication costs does not constitute the practice of medicine or pharmacy by Signos. Results may vary and depend on individual adherence, independent provider guidance, and lifestyle changes. Unless otherwise noted, results referenced reflect individual Signos patient experiences rather than public clinical studies, and no particular outcome is guaranteed.
Nothing on this website or within the Signos platform should be construed as medical advice, a medical diagnosis, or a recommendation for any specific treatment. If you are experiencing a medical emergency, call 911 or your local emergency services immediately.