You've lost the weight. Now keep it off.
Graduate from GLP‑1s without the rebound. Signos gives you the metabolic visibility to keep the weight off—for good.
Start Your GraduationMost people regain any lost weight within 1.7 years after stopping GLP‑1s1 without a plan. Don't be one of them.
You've lost the weight. Now keep it off.
Graduate from GLP‑1s without the rebound. Signos gives you the metabolic visibility to keep the weight off—for good.
Most people regain any lost weight within 1.7 years after stopping GLP‑1s1 without a plan. Don't be one of them.
GLP‑1s Were Never Meant To Be Forever
GLP‑1s have been praised for silencing “food noise,” suppressing appetite, and balancing blood sugar. But around 50% of people stop treatment after just 12 months due to nasty side effects, high cost, safety concerns, or plateaued results. And here's what happens when you stop taking them:
How much quicker weight returns after stopping medication compared to stopping a behavioral lifestyle program
The average time it takes for people to return to their baseline weight after stopping treatment
The time it takes for blood sugar and blood pressure to return to unhealthy baseline levels after stopping
Here's What Signos Does That GLP‑1s Can't
While GLP‑1s manage your glucose, appetite, and cravings, Signos actually shows you what's impacting them—so you can stay in control after treatment has stopped.
Know exactly what's spiking your glucose
24/7 glucose data delivered to your phone reveals important patterns, and voice logging makes tracking meals so easy you'll actually do it.
Fewer cravings, crashes, and post-meal spikes
GLP‑1s flatten the post-meal spike but won't tell you what caused it. Your CGM will, so you actually know how to stabilize your glucose.
Insights that connect the dots
Real-time movement alerts, sleep tracking, and personalized health reports show how your daily habits are impacting your glucose.
Motivation and habits that outlast GLP‑1s
1:1 in-app dietitian support turns your data into clear, personalized guidance so the changes you make actually stick.
Don't leave your results to chance.
See Plans
Glucose and Weight
Glucose plays a central role in how your body uses energy, manages hunger, and stores fat.
When glucose stays elevated or spikes frequently, your body shifts into storage mode and it becomes harder to make progress toward your weight goals.
Stabilizing glucose helps your body work with you, unlocking sustainable progress you can actually feel.
Glucose and Weight
Glucose plays a central role in how your body uses energy, regulates appetite, and stores fat.
When glucose stays elevated or spikes frequently, it becomes harder to make progress toward your weight goals.
Stabilizing glucose helps unlock real, sustainable weight outcomes.
Stabilize Your Glucose. Reach Your Weight Goals. Meet Signos.
Understand how food, movement, sleep, and daily habits affect your glucose and where spikes may be making progress harder.
Learn which foods, routines, and habits help stabilize glucose, support fat loss, and keep your metabolism working with you, not against you.
With real-time guidance from Signos, you turn simple daily decisions into predictable progress you can sustain over time.
A Smarter Way Off GLP‑1s
Three pillars that work together to ensure lasting success
- Step 01
Wear your CGM and live your life
Your continuous glucose monitor tracks while you do you. Eating, exercising, sleeping, stressed — it captures how your glucose responds to all of it in real time. No logging required.
- Step 02
Get an AI score for every meal
After you eat, Signos scores the meal based on your personal glucose response — not generic nutrition rules. See exactly which foods spike your glucose and which keep it steady, so every meal becomes a learning opportunity.
- Step 03
Follow your weight loss signal and make it last
Signos shows you when your body is in the optimal zone for burning fat, giving you a clear signal and the confidence to act on it. The goal is understanding your metabolism well enough to make changes that truly last.
Ready to graduate?
Get Started
What Doctors Wish You Knew
Developed by researchers at:
Glucose stabilization is the key for successful and sustainable weight loss. The Signos platform can help people short-circuit the cycle of excess weight, glucose intolerance, insulin resistance, and the storage of excess dietary glucose and triglycerides as fat. The best ‘diets’ are the ones that help you lose weight and that you can sustain.”
– William Dixon, MD
Stanford Physician, Diplomate of the American Board of Obesity Medicine
Real Data. Real Change. Real Members.
Real Data.
Real Change.
Real Members.
4.8 out of 5 stars
Frequently Asked Questions
Your Questions Answered
Many programs give you generic rules to follow: Cut carbs, count calories, “eat less, move more.” And it probably worked for a bit…until it didn't. That’s because these rules don't tell you why your body responds the way that it does to food, meal timing, sleep, stress, and movement. Signos shows you how your glucose responds to specific foods, in real time.
So when you see that brown rice spikes glucose but white rice doesn't, or that stress spikes your blood sugar as much as a candy bar, you stop following those one-size-fits-all rules and start adopting rules that finally work with your biology.
Absolutely! Blood sugar crashes are often to blame for relentless cravings and persistent hunger. When you can see the pattern in your data, you can stop it with a short walk or a different food choice in the future. You also see how sleep and stress impact your hunger and cravings, too.
When glucose spikes, your pancreas releases insulin, your primary fat storage hormone, to bring it back down. Frequent blood sugar spikes turn on your body’s “fat-storing mode.” GLP-1s work by flattening post-meal spikes by slowing gastric emptying, but Signos can also lessen post-meal spikes by showing you exactly what foods are impacting your glucose, so you can avoid them.
When you’re not spiking and crashing, you’re not getting the reactive hunger that feels urgent and hard to ignore. For a lot of people, that “food noise” is really just glucose dysregulation. Stabilize your glucose, and the food noise quiets down.
Either works. If you're still tapering, starting now gives you a real-time read on how your body is responding as your dose drops. If you've already stopped, we can help you build metabolic awareness so you can avoid the rebound.
Graduate With Signos
GLP‑1s were just the beginning. Keep the results and gain the knowledge you need to take your metabolic health into your own hands.
Get Signos Now
Don't miss out!
Sign up to be the first to know about special offers and exciting Signos news.
Copyright © 2026 Signos Inc.
Signos indications: The Signos Glucose Monitoring System is an over-the-counter (OTC) mobile device application that receives data from an integrated Continuous Glucose Monitor (iCGM) sensor and is intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Signos Glucose Monitoring System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Signos Glucose Monitoring System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursions. This information may be useful in helping users to maintain a healthy weight.
The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
See user guide for important warnings and precautions.
STELO IMPORTANT INFORMATION: Consult your healthcare provider before making any medication adjustments based on your sensor readings and do not take any other medical action based on your sensor readings without consulting your healthcare provider. Do not use if you have problematic hypoglycemia. Failure to use Stelo and its components according to the instructions for use provided and to properly consider all indications, contraindications, warnings, and cautions in those instructions for use may result in you missing a severe hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose) occurrence. If your sensor readings are not consistent with your symptoms, a blood glucose meter may be an option as needed and consult your healthcare provider. Seek medical advice and attention when appropriate, including before making any medication adjustments and/or for any medical emergency.
STELO INDICATIONS FOR USE: The Stelo Glucose Biosensor System is an over-the-counter (OTC) integrated Continuous Glucose Monitor (iCGM) intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Stelo Glucose Biosensor System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Stelo Glucose Biosensor System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursion. The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
OPENLOOP CLINICAL AND PHARMACEUTICAL SERVICES:
Signos is a technology platform and wellness program provider. With the exception of registered dieticians, Signos does not employ licensed health care professionals to practice medicine, does not diagnose, treat, cure, or prevent any disease or medical condition, and does not provide medical advice. You should always consult your own health care professional for diagnosis, treatment, and care regarding any medical condition or health concern. Clinical services accessible through the Signos platform are provided solely by OpenLoop Health and other independent networks of U.S.-licensed clinicians, who exercise their own independent medical judgment to determine eligibility for GLP‑1 treatment based on medical history and assessment responses. These independent providers retain full discretion to prescribe or decline compounded GLP‑1 medications. Signos does not direct, control, or influence any clinical decision made by these providers, and no provider-patient relationship is created between you and Signos.
Compounded medications that may be made available in connection with the Signos program are produced in FDA-registered facilities, but are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. Signos does not manufacture, compound, dispense, or distribute any medications. Signos partners with certified U.S. pharmacies to help facilitate access to these medications, but Signos makes no representations or warranties regarding the safety, efficacy, suitability, or quality of any compounded medication. Product appearance may differ from website images.
Medication costs are included in the Signos program; however, inclusion of medication costs does not constitute the practice of medicine or pharmacy by Signos. Results may vary and depend on individual adherence, independent provider guidance, and lifestyle changes. Unless otherwise noted, results referenced reflect individual Signos patient experiences rather than public clinical studies, and no particular outcome is guaranteed.
Nothing on this website or within the Signos platform should be construed as medical advice, a medical diagnosis, or a recommendation for any specific treatment. If you are experiencing a medical emergency, call 911 or your local emergency services immediately.