Learn how your food choices, movement patterns, sleep quality, and stress responses shape your blood sugar (glucose) throughout the day. With clear visibility into these signals, you can make targeted adjustments to your nutrition and daily habits that support more stable glucose levels. Over time, these small, consistent changes can lead to meaningful improvements in metabolic health, sustainable weight loss, and overall well-being.
This is the Signos approach to healthy weight management whether losing it or keeping it off. Our personalized program is grounded in a rapidly expanding body of scientific research on metabolism, glucose regulation, and behavior change—with new studies emerging every year.
Explore the latest scientific evidence behind using CGMs to support weight loss.
Glucose is your body’s primary source of energy. It travels through the bloodstream to fuel your cells, and several hormones—most notably insulin—work together to keep glucose levels within a healthy range.
Step 1
You eat a meal.
Carbohydrates, along with some proteins, are digested and converted into glucose.
Step 2
Glucose enters the bloodstream.
Glucose enters the bloodstream. As digestion progresses, glucose is released into your blood, raising your blood sugar levels.
Step 3
Your pancreas responds.
Rising glucose signals the pancreas to release insulin, the hormone that helps your body use or store energy.
Step 4
Insulin unlocks your cells.
Insulin helps move glucose from the bloodstream into your cells, where it can be used immediately for energy or stored for later.
Step 5
Blood sugar returns to baseline.
As glucose is taken up by cells, blood sugar levels gradually return to a healthy, stable range
Glucose is the body’s preferred energy source. Your cells burn it to power everything from muscle contraction to brain function. When you need energy right away, glucose is used immediately. When you don’t, your body shifts into storage mode.
Short-term storage:
Excess glucose is stored in your liver and muscles as glycogen, a quick-access fuel reserve.
Long-term storage: Once glycogen stores are full, additional glucose is converted into fat (adipose tissue). Over time, this process is one pathway through which excess glucose contributes to weight gain.
Frequent spikes: Meals high in sugar or refined carbohydrates can trigger rapid glucose surges, followed by energy crashes. These swings often drive fatigue, hunger, and cravings—making it harder to regulate your eating patterns.
Insulin resistance: Repeated or prolonged high glucose levels can make cells less responsive to insulin. This reduced sensitivity (known as insulin resistance) forces the pancreas to work harder and can eventually progress to type 2 diabetes.
Fat storage: Elevated insulin levels encourage the body to store energy as fat and make fat burning more difficult.
Inflammation & metabolic stress: Chronically elevated glucose contributes to inflammation, higher triglyceride levels, and other metabolic disruptions associated with cardiovascular disease.
Want to learn more?
People need a personalized solution for weight management. The Signos platform can help people short-circuit the cycle of excess weight, glucose intolerance, insulin resistance, and the storage of excess dietary glucose and triglycerides as fat.
The best 'diets' are the ones that help you lose weight and that you can sustain. The most effective weight loss apps are the ones that hold you accountable and encourage behavior change.
Signos provides real-time feedback while the app experience builds accountability and instigates sustainable lifestyle change that can result in weight loss.
- William Dixon, MD
Stanford Physician, Diplomate of the American Board of Obesity Medicine
Glucose spikes—or a rapid rise in the amount of glucose in the body—cause proportional insulin release. Glucose that isn’t used by activity gets stored for later use, sometimes as fat.
Your brain constantly monitors blood glucose and adjusts appetite and energy use in response. When glucose spikes and crashes—often after meals high in sugar or refined carbs—your body can experience sudden hunger, cravings, and a tendency to overeat. Over time, these fluctuations make it harder to maintain a healthy weight.
Keeping glucose levels stable helps your brain send consistent satiety signals, reducing unnecessary hunger and supporting better portion control. Stable glucose also prevents energy crashes that can derail exercise, daily activity, and healthy habits.
Frequent spikes and crashes in glucose levels (often caused by high-glycemic foods) can leave your energy and mood swinging throughout the day. Keeping glucose stable supports consistent energy, sharper focus, and a more balanced mood from morning to night.
Want to learn more?
Continuous glucose monitors (CGM) do more than track your blood sugar; they provide actionable insights. Research shows that using a CGM can help guide behavior changes, including healthier eating, consistent exercise, and more mindful lifestyle choices, all of which support weight management and long-term metabolic health.
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Signos indications: The Signos Glucose Monitoring System is an over-the-counter (OTC) mobile device application that receives data from an integrated Continuous Glucose Monitor (iCGM) sensor and is intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Signos Glucose Monitoring System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Signos Glucose Monitoring System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursions. This information may be useful in helping users to maintain a healthy weight.
The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
See user guide for important warnings and precautions.
STELO IMPORTANT INFORMATION: Consult your healthcare provider before making any medication adjustments based on your sensor readings and do not take any other medical action based on your sensor readings without consulting your healthcare provider. Do not use if you have problematic hypoglycemia. Failure to use Stelo and its components according to the instructions for use provided and to properly consider all indications, contraindications, warnings, and cautions in those instructions for use may result in you missing a severe hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose) occurrence. If your sensor readings are not consistent with your symptoms, a blood glucose meter may be an option as needed and consult your healthcare provider. Seek medical advice and attention when appropriate, including before making any medication adjustments and/or for any medical emergency.
STELO INDICATIONS FOR USE: The Stelo Glucose Biosensor System is an over-the-counter (OTC) integrated Continuous Glucose Monitor (iCGM) intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Stelo Glucose Biosensor System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Stelo Glucose Biosensor System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursion. The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
OPENLOOP CLINICAL AND PHARMACEUTICAL SERVICES:
Signos is a technology platform and wellness program provider. With the exception of registered dieticians, Signos does not employ licensed health care professionals to practice medicine, does not diagnose, treat, cure, or prevent any disease or medical condition, and does not provide medical advice. You should always consult your own health care professional for diagnosis, treatment, and care regarding any medical condition or health concern. Clinical services accessible through the Signos platform are provided solely by OpenLoop Health and other independent networks of U.S.-licensed clinicians, who exercise their own independent medical judgment to determine eligibility for GLP‑1 treatment based on medical history and assessment responses. These independent providers retain full discretion to prescribe or decline compounded GLP‑1 medications. Signos does not direct, control, or influence any clinical decision made by these providers, and no provider-patient relationship is created between you and Signos.
Compounded medications that may be made available in connection with the Signos program are produced in FDA-registered facilities, but are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. Signos does not manufacture, compound, dispense, or distribute any medications. Signos partners with certified U.S. pharmacies to help facilitate access to these medications, but Signos makes no representations or warranties regarding the safety, efficacy, suitability, or quality of any compounded medication. Product appearance may differ from website images.
Medication costs are included in the Signos program; however, inclusion of medication costs does not constitute the practice of medicine or pharmacy by Signos. Results may vary and depend on individual adherence, independent provider guidance, and lifestyle changes. Unless otherwise noted, results referenced reflect individual Signos patient experiences rather than public clinical studies, and no particular outcome is guaranteed.
Nothing on this website or within the Signos platform should be construed as medical advice, a medical diagnosis, or a recommendation for any specific treatment. If you are experiencing a medical emergency, call 911 or your local emergency services immediately.
