A smarter way to reach your weight goals
Signos uses your body's most important metabolic signal, glucose, to help you achieve and maintain real results.
A smarter way to reach your weight goals
Get StartedSignos uses your body's most important metabolic signal, glucose, to help you achieve and maintain real results.
Stabilize Your Glucose.
Reach Your Weight Goals. Meet Signos.
See what's contributing to your weight
Understand how food, movement, sleep, and daily habits affect your glucose and where spikes may be making progress harder.
Build habits that support fat loss
Learn which foods, routines, and habits help stabilize glucose, support fat loss, and keep your metabolism working with you, not against you.
Achieve and maintain meaningful weight loss
With real-time guidance from Signos, you turn simple daily decisions into predictable progress you can sustain over time.
Glucose and Weight
Glucose plays a central role in how your body uses energy, regulates appetite, and stores fat.
When glucose stays elevated or spikes frequently, it becomes harder to make progress toward your weight goals.
Stabilizing glucose helps unlock real, sustainable weight outcomes.
Your Path to Lasting Results
- Step 01
Wear your CGM and live your life
Your continuous glucose monitor tracks while you do you. Eating, exercising, sleeping, stressed — it captures how your glucose responds to all of it in real time. No logging required.
- Step 02
Get an AI score for every meal
After you eat, Signos scores the meal based on your personal glucose response — not generic nutrition rules. See exactly which foods spike your glucose and which keep it steady, so every meal becomes a learning opportunity.
- Step 03
Follow your weight loss signal and make it last
Signos shows you when your body is in the optimal zone for burning fat, giving you a clear signal and the confidence to act on it. The goal is understanding your metabolism well enough to make changes that truly last.
Insights Turn Into Real Progress
Kim, 51
Before: Weight gain during hormonal changes. Old strategies stopped working.
One Signos insight: Seeing real glucose data made food decisions clear, not guesswork.
After: Steady weight loss by adjusting habits with confidence.
Real Data. Real Change. Real Members.
Real Data.
Real Change.
Real Members.
4.8 out of 5 stars
Frequently Asked Questions
Your Questions Answered
Signos is a real-time metabolic health platform that combines an AI-powered app with a continuous glucose monitor (CGM). Your glucose data is sent directly to the app and combined with hundreds of millions of data points to predict responses to food and movement, track trends, log meals, track your weight, and access science-backed guidance to build sustainable, glucose-stable habits. You can also sync with Apple Health, Google Health Connect, smartwatches, and smart scales for a more complete view of your health.
Signos uses glucose data and millions of data points from logged meals, workouts, and other habits to deliver personalized guidance. When something you eat spikes your glucose, the app can suggest the right type and intensity of movement (based on your history) to help bring it back down. Over time, keeping your glucose more stable can lead to better energy, sharper focus, improved metabolic health, reduced risk of chronic conditions, and sustainable weight management.
Read more about how Signos works.
Yes, when used consistently, CGMs (also known as biosensors) can support healthy, sustainable weight management by helping you understand how your body responds to food, exercise, and daily habits in real time.
Research shows that 87% of CGM users change their food choices based on glucose feedback, and nearly half are more likely to move their bodies when they see a spike. Over 90% of users say CGMs help them lead a healthier lifestyle.
By showing you when your glucose rises or crashes, CGMs make it easier to recognize patterns, like cravings driven by glucose dips or energy crashes, and to respond with small, effective adjustments. This kind of insight can help you delay eating when your body still has fuel to burn, choose foods that support more stable glucose, and use short bursts of movement to bring high glucose levels back down.
Signos takes that a step further by using your personal glucose data, meal logs, and workout history to suggest what to eat next or how to move, so you’re not guessing. With consistent use, CGMs paired with in-the-moment guidance can help retrain your appetite, reduce overeating, and build habits that support long-term weight and fat loss.
For the latest information regarding the science behind glucose, insulin, fat storage, and weight loss, read The Scientific Evidence for Using CGMs for Weight Loss.
Possibly, but it depends on your HSA/FSA provider. Coverage varies, so check with your provider to confirm whether CGMs and wellness programs like Signos are eligible.
Please note: Signos is not responsible for reimbursement, and the cancellation policy and terms still apply, even if your provider does not approve coverage or reimbursement.
If weight loss is your goal, consider the amount of weight you’d like to lose and the recommended pace of 1 to 2 pounds per week. For example, a 25-pound weight loss goal is typically well supported by a 6-month plan. All plans give you full access to the Signos platform and behavior change program for the duration of your subscription.
What Doctors Wish You Knew
Developed by researchers at:
Glucose stabilization is the key for successful and sustainable weight loss. The Signos platform can help people short-circuit the cycle of excess weight, glucose intolerance, insulin resistance, and the storage of excess dietary glucose and triglycerides as fat. The best ‘diets’ are the ones that help you lose weight and that you can sustain.”
– William Dixon, MD
Stanford Physician, Diplomate of the American Board of Obesity Medicine
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Signos indications: The Signos Glucose Monitoring System is an over-the-counter (OTC) mobile device application that receives data from an integrated Continuous Glucose Monitor (iCGM) sensor and is intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Signos Glucose Monitoring System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Signos Glucose Monitoring System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursions. This information may be useful in helping users to maintain a healthy weight.
The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
See user guide for important warnings and precautions.
STELO IMPORTANT INFORMATION: Consult your healthcare provider before making any medication adjustments based on your sensor readings and do not take any other medical action based on your sensor readings without consulting your healthcare provider. Do not use if you have problematic hypoglycemia. Failure to use Stelo and its components according to the instructions for use provided and to properly consider all indications, contraindications, warnings, and cautions in those instructions for use may result in you missing a severe hypoglycemia (low blood glucose) or hyperglycemia (high blood glucose) occurrence. If your sensor readings are not consistent with your symptoms, a blood glucose meter may be an option as needed and consult your healthcare provider. Seek medical advice and attention when appropriate, including before making any medication adjustments and/or for any medical emergency.
STELO INDICATIONS FOR USE: The Stelo Glucose Biosensor System is an over-the-counter (OTC) integrated Continuous Glucose Monitor (iCGM) intended to continuously measure, record, analyze, and display glucose values in people 18 years and older not on insulin. The Stelo Glucose Biosensor System helps to detect normal (euglycemic) and low or high (dysglycemic) glucose levels. The Stelo Glucose Biosensor System may also help the user better understand how lifestyle and behavior modification, including diet and exercise, impact glucose excursion. The user is not intended to take medical action based on the device output without consultation with a qualified healthcare professional.
OPENLOOP CLINICAL AND PHARMACEUTICAL SERVICES:
Signos is a technology platform and wellness program provider. With the exception of registered dieticians, Signos does not employ licensed health care professionals to practice medicine, does not diagnose, treat, cure, or prevent any disease or medical condition, and does not provide medical advice. You should always consult your own health care professional for diagnosis, treatment, and care regarding any medical condition or health concern. Clinical services accessible through the Signos platform are provided solely by OpenLoop Health and other independent networks of U.S.-licensed clinicians, who exercise their own independent medical judgment to determine eligibility for GLP‑1 treatment based on medical history and assessment responses. These independent providers retain full discretion to prescribe or decline compounded GLP‑1 medications. Signos does not direct, control, or influence any clinical decision made by these providers, and no provider-patient relationship is created between you and Signos.
Compounded medications that may be made available in connection with the Signos program are produced in FDA-registered facilities, but are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality. Signos does not manufacture, compound, dispense, or distribute any medications. Signos partners with certified U.S. pharmacies to help facilitate access to these medications, but Signos makes no representations or warranties regarding the safety, efficacy, suitability, or quality of any compounded medication. Product appearance may differ from website images.
Medication costs are included in the Signos program; however, inclusion of medication costs does not constitute the practice of medicine or pharmacy by Signos. Results may vary and depend on individual adherence, independent provider guidance, and lifestyle changes. Unless otherwise noted, results referenced reflect individual Signos patient experiences rather than public clinical studies, and no particular outcome is guaranteed.
Nothing on this website or within the Signos platform should be construed as medical advice, a medical diagnosis, or a recommendation for any specific treatment. If you are experiencing a medical emergency, call 911 or your local emergency services immediately.