Circadian Rhythm: Unlocking Its Role in Metabolic Health

Discover how your circadian rhythm influences metabolic health, weight management, and energy levels, and how syncing with your body’s internal clock can lead to lasting results.

woman sleeping in bed
by
Caroline Thomason
— Signos
Dietician + Diabetes Educator (CDCES)
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Updated by

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Science-based and reviewed

Updated:
Published:
June 9, 2025
June 9, 2025

Table of Contents

Key Takeaways

  • Circadian rhythms are internal clocks that influence everything from sleep to metabolism, and maintaining their alignment can support overall health.
  • Disruptions to circadian rhythms, like shift work or late-night eating, can increase the risk of metabolic disorders such as obesity and type 2 diabetes.
  • You can support your circadian rhythm with simple lifestyle adjustments, such as maintaining a consistent sleep schedule, exposing yourself to early morning light, and aligning meals with your natural wake-sleep cycle.

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You can think of your circadian rhythm as your body's natural timekeeper. Considering your daily routine, your circadian rhythm can help orchestrate everything from hormone releases that impact your appetite and energy levels. Your circadian rhythm follows a daily 24-hour cycle, influencing nearly all aspects of your overall health.1

When you're in sync with your natural sleep-wake cycle, you'll feel more energized, focused, and metabolically balanced. When you're out of sync with your central clock, you may notice increased fatigue, mood swings, food cravings, and blood sugar issues that begin to appear.

If you’re experiencing circadian misalignment, you might be at an increased risk for cardio-metabolic concerns, metabolic syndrome, blood glucose risk factors, and other endocrinology concerns.1 Let's break down why circadian rhythms matter for your metabolic health and habits, and how you can put them into place to keep yours in balance.

What Are Circadian Rhythms?

Your circadian clock is your biological time regulation system that operates on a 24-hour schedule each day. Controlled by a part of the brain called the suprachiasmatic nucleus (SCN), these daily clocks influence your sleep, body temperature, insulin secretion, hunger hormones such as ghrelin, and physical activity. They respond to external cues, such as sunlight and the timing of your food schedule throughout the day. That means that your daily habits can either help or hinder how your body functions in relation to your circadian rhythm.

Circadian Rhythms and Metabolic Processes

Your metabolic health isn't just about the calories you've taken and the calories you burn. It's a tightly regulated system that is influenced by our body’s natural rhythms. Your habits and behaviors are big inputs for your endocrine system, which also impacts how your metabolic homeostasis functions.2,3

Hormones like insulin and cortisol follow the lead of our circadian timing patterns. They impact body weight over time, blood pressure, and metabolic dysfunction.2,3 For example, insulin sensitivity is higher when you wake up, allowing you to process carbohydrates more efficiently in the morning compared to nighttime. Eating, sleeping, and exercising in sync with your internal clocks makes a significant difference in how your body functions.

Consequences of Circadian Disruption on Metabolic Health

When your circadian rhythm is out of sync with your daily behaviors or environment, it can disrupt your metabolic system. We often experience this when our schedule is disrupted or if we undergo major lifestyle changes.

Here are a few examples of times when your circadian rhythm may be disrupted and how it can impact metabolic health.

Shift Work and Jet Lag

Working at night or traveling across multiple time zones can disrupt your natural light-dark cycle. If your body is expecting to sleep and rest when it's dark outside, but you are pushing through and working, your hormonal rhythms get disrupted. 

Studies show that folks who work the night shift or often travel, for example, on a redeye flight, may be at a greater risk for increased insulin resistance, weight gain, or cardiovascular disease. However, there may be a correlation here that doesn't necessarily mean causation. You still have control over lifestyle behaviors, such as what you eat and how you exercise, to impact your metabolic health.

Sleep Deprivation

Not getting enough sleep, or not getting enough high-quality sleep, doesn't just make you groggy; it also disrupts blood sugar regulation and increases your stress hormone, cortisol. The stress response can also increase your appetite, leading you to crave high-energy, high-carb foods. 

For individuals in a season of life where sleep deprivation is unavoidable, such as new parents, you may notice some of these changes. However, once you're able to get back on track, your metabolic health can change for the better.

Late-Night Eating

Your digestive system also operates on a natural rhythm. Eating heavy, high-carbohydrate meals at night when your body is less ready to process food can lead to blood sugar spikes overnight. Research suggests that late-night eaters are more likely to gain weight and store fat, likely due to the types of choices they make, rather than the time of day they eat.

If you fall into one of these categories, there are still many things you can do to improve your health and have control over your circadian rhythm and metabolism. Don't lose hope because of your crazy schedule, but rather let's discuss strategies you can implement to help boost your metabolism now.

6 Strategies to Align Circadian Rhythms for Metabolic Health

Sometimes life happens, and you can't always perfectly regulate your circadian rhythm for metabolic health. However, you can focus on simple, science-backed habits that help you build routines and regulate your hormones throughout the day.

Here are a few science-backed tips that help regulate circadian rhythm and may, in turn, impact your metabolic health.5

  • Stick to consistent sleep and wake times: Your body loves routine. Waking and sleeping at the same time every day, even on weekends, helps reinforce your internal clock and regulate hormones like cortisol and melatonin. Just like kids thrive on a consistent bedtime routine, so do adults.
  • Get sunlight exposure early in the day: Sunlight is one of the strongest signals to your brain that it’s time to be awake. Aim to get outside for 10 to 30 minutes in the morning, whether it’s a walk, coffee on the porch, or just standing by a bright window. 
  • Eat meals at regular times: Try to keep meals around the same time each day, and aim to finish your last meal at least two to three hours before bedtime. This can help regulate the metabolic pathways of hunger and fullness through hormones like ghrelin and leptin. Meal timing and eating within a 10- to 12-hour window can help synchronize your metabolic and circadian systems, a practice sometimes referred to as time-restricted eating or circadian eating.4
  • Avoid large meals late at night: Digestion slows down in the evening, and consuming large meals late at night can lead to blood sugar spikes, poor sleep, and increased fat storage. Eating at night may increase the risk of metabolic disease by affecting glucose tolerance. If you’re hungry before bed, opt for a small snack with a little protein or complex carbohydrates, such as Greek yogurt or a slice of whole-grain toast with almond butter.
  • Limit screen time an hour before bed: Blue light from phones, tablets, and TVs tricks your brain into thinking it’s still daytime, suppressing melatonin (your body’s natural sleep hormone). Try swapping screen time for wind-down activities, such as reading, stretching, or journaling. If you must be on screens, consider blue-light-blocking glasses or using night mode.
  • Incorporate daily movement: Regular activity helps improve sleep quality and supports metabolic health, but intense workouts late at night can be too stimulating. If evenings are your only window, try calming movements like yoga or walking instead of high-intensity intervals.

The Bottom Line

Your daily rhythms aren’t just about how you sleep. They’re a foundational element of your metabolic health. Disruptions can lead to blood sugar swings, weight gain, and increased chronic disease risk. But by realigning your daily habits to match your body’s natural clock, you can support energy, focus, and long-term health.

Learn More With Signos’ Expert Advice

Your blood sugar and your circadian rhythm are more connected than you think. Signos helps you monitor how your lifestyle choices affect your glucose levels in real-time, providing personalized insights to support your metabolic health.

Read Next: Do women need more sleep?

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References

  1. Schrader LA, Ronnekleiv-Kelly SM, Hogenesch JB, Bradfield CA, Malecki KM. Circadian disruption, clock genes, and metabolic health. J Clin Invest. 2024 Jul 15;134(14):e170998. 
  2. Reutrakul S, Knutson KL. Consequences of Circadian Disruption on Cardiometabolic Health. Sleep Med Clin. 2015 Dec;10(4):455-68. 
  3. Škrlec I, Talapko J, Džijan S, Cesar V, Lazić N, Lepeduš H. The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis. Biology (Basel). 2021;11(1):20. Published 2021 Dec 24. 
  4. Chang Y, Du T, Zhuang X, Ma G. Time-restricted eating improves health because of energy deficit and circadian rhythm: A systematic review and meta-analysis. iScience. 2024;27(2):109000. Published 2024 Jan 26.
  5. Yuan RK, Pardilla-Delgado E, Zitting KM, Duffy JF. Tips for circadian sleep health while working from home. Southwest J Pulm Crit Care. 2020;20(4):126-127.

About the author

Caroline Thomason is a dietitian, diabetes educator, and health writer based in Washington, DC.

View Author Bio

Please note: The Signos team is committed to sharing insightful and actionable health articles that are backed by scientific research, supported by expert reviews, and vetted by experienced health editors. The Signos blog is not intended to diagnose, treat, cure or prevent any disease. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider. Read more about our editorial process and content philosophy here.

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