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May 28, 2024
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GLP-1
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3 min read
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Rybelsus and Food: What to Eat and Avoid

Woman taking a pill with a glass of water near.

As a diabetes medication that can significantly impact blood glucose levels, understanding how to best support Rybelsus with diet is crucial for individuals managing type 2 diabetes. Rybelsus, a GLP-1 receptor agonist, works to lower blood sugar levels and promote weight loss by slowing down stomach emptying and reducing appetite. Pairing Rybelsus with appropriate food choices can enhance its effectiveness and minimize potential side effects. In this article, we'll explore the foods that complement Rybelsus' mechanism of action, as well as those to avoid to ensure optimal management of type 2 diabetes.

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What Is Rybelsus?

Rybelsus is a brand name for the active ingredient semaglutide, which is a prescription drug used to treat type 2 diabetes. It is not available as an over-the-counter medication. It belongs to a class of drugs called GLP-1 receptor agonists, which work by mimicking the action of a hormone called glucagon-like peptide-1. GLP-1 is normally released in the intestines in response to food intake and helps regulate blood sugar levels and encourage weight loss. However, it’s important to note that Rybelsus has not been specifically FDA-approved for weight loss.

Rybelsus tablets are an oral medication, which is unique among GLP-1 receptor agonists, as others, such as Ozempic or Wegovy, are typically administered by injection. Like Ozempic or Wegovy, it works by delaying gastric emptying, reducing appetite, and lowering blood sugar levels. This can lead to improved glycemic control and may also result in weight loss, which can be beneficial for people with type 2 diabetes who are overweight or obese. Rybelsus is often used alongside diet and exercise to help manage blood sugar levels in adults with type 2 diabetes. It is not intended for use in people with type 1 diabetes or diabetic ketoacidosis.

Why Do You Have to Take Rybelsus on an Empty Stomach?

Does Rybelsus need to be taken on an empty stomach? Taking semaglutide on an empty stomach is recommended because food can interfere with its absorption and effectiveness. Semaglutide works by slowing down the emptying of the stomach and reducing appetite, which can help control blood sugar levels and promote weight loss in people with type 2 diabetes. When taken on an empty stomach, Rybelsus has a better chance of being absorbed into the bloodstream before food enters the stomach and starts the digestion process. This allows it to exert its effects more efficiently.

Additionally, taking Rybelsus with food can increase the risk of gastrointestinal side effects, such as nausea, vomiting, and constipation. These side effects are more likely to occur when Rybelsus comes into contact with food in the stomach, potentially leading to discomfort and reduced medication adherence. Therefore, taking Rybelsus on an empty stomach not only improves its absorption and effectiveness but also helps minimize the risk of gastrointestinal side effects, enhancing the overall treatment experience for people with type 2 diabetes.

6 Foods to Eat While Taking Rybelsus

A plate of cooked fish, broccoli and potatoes.

Choosing the right foods to complement Rybelsus (semaglutide) can enhance its effectiveness in managing type 2 diabetes and promoting weight loss. Incorporating nutrient-dense foods that support blood sugar regulation and satiety can optimize the benefits of Rybelsus. In this section, we'll explore six key foods that can help you make the most of your Rybelsus treatment.

  • High-Fiber Foods: Foods rich in fiber, such as whole grains, fruits, vegetables, and legumes, can help slow down the emptying of the stomach and improve satiety, which may complement Rybelsus' effects on appetite and blood sugar control.
  • Lean Proteins: Including lean proteins like chicken, fish, tofu, and legumes in your diet can help promote satiety and support muscle maintenance, which is important for overall health and weight management.
  • Healthy Fats: Foods rich in healthy fats, such as avocados, nuts, seeds, and olive oil, can help enhance the absorption of fat-soluble vitamins and provide sustained energy, which may be beneficial when taking Rybelsus.
  • Low-Glycemic Index (GI) Foods: Choosing foods with a low GI, such as non-starchy vegetables, whole grains, and legumes, can help stabilize blood sugar levels and reduce the risk of spikes and crashes, complementing Rybelsus' effects on blood sugar control.
  • Probiotic-Rich Foods: Including probiotic-rich foods like yogurt, kefir, and sauerkraut in your diet can help support gut health, which is important for overall digestion and nutrient absorption, potentially enhancing the benefits of Rybelsus.
  • Hydrating Foods: Foods with high water content, such as cucumbers, watermelon, and soups, can help promote hydration, which is important when taking Rybelsus.

<p class="pro-tip"><strong>Learn More: </strong><a href=supplements-and-foods-that-increase-glp-1>Supplements and Foods That Increase Glp-1 Naturally</a>.</p>

What Foods Should You Avoid While Taking Rybelsus?

Certain foods can interfere with Rybelsus' effectiveness in regulating blood sugar levels and controlling appetite, while others may exacerbate common side effects, such as gastrointestinal issues. By identifying and avoiding these problematic foods, individuals can better support their treatment plan and enhance the benefits of Rybelsus. In this section, we'll explore the foods that should be limited or avoided while taking Rybelsus.

  • Highly Processed Foods: Foods that are high in refined sugars and unhealthy fats, such as sugary drinks, pastries, and fast food, can lead to rapid spikes in blood sugar levels and may counteract Rybelsus' ability to regulate blood sugar.
  • Highly Acidic Foods: Foods that are highly acidic, such as citrus fruits and tomatoes, can irritate the stomach lining and potentially exacerbate gastrointestinal side effects, such as nausea and vomiting, which are common with Rybelsus.
  • High-Fat Foods: While healthy fats are beneficial, foods that are high in unhealthy fats, such as fried foods and fatty cuts of meat, can slow down stomach emptying and may reduce the effectiveness of Rybelsus in regulating appetite and blood sugar.
  • Alcohol: Drinking alcohol can interfere with the metabolism of Rybelsus and may increase the risk of hypoglycemia (low blood sugar) when consumed in excess. It's important to consume alcohol in moderation and monitor blood sugar levels closely.
  • Large Meals: Consuming large meals, especially high-calorie or high-carb meals, can overwhelm the stomach and may lead to discomfort or gastrointestinal side effects when taking Rybelsus. It's recommended to eat smaller, more frequent meals to support digestion and blood sugar control.
  • Spicy Foods: Spicy foods can irritate the stomach lining and may exacerbate gastrointestinal side effects, such as nausea and acid reflux, which are common with Rybelsus. It's best to avoid overly spicy foods or consume them in moderation.

6 Tips for Taking Rybelsus

woman at breakfast table opening a pill container with glass of water on the side.

Taking Rybelsus can be an important part of managing type 2 diabetes, but it's essential to use it effectively to maximize its benefits and minimize potential serious side effects. These tips can help you navigate your Rybelsus treatment more smoothly, ensuring that you get the most out of this medication.

  • Take it on an Empty Stomach: To ensure optimal absorption and effectiveness, take Rybelsus at least 30 minutes before your first meal, drink, or other medication of the day. This allows the medication to start working before food enters your stomach, which can enhance its effects on appetite and blood sugar control.
  • Stay Consistent With Timing: Try to take Rybelsus at the same time each day to maintain a consistent level of medication in your body. This can help regulate your appetite and blood sugar levels more effectively over time.
  • Swallow the Tablet Whole: Do not crush, chew, or break the tablet, as this can affect its release and absorption in the body. Swallow it whole with a glass of water to ensure it reaches your stomach intact.
  • Stay Hydrated: Drink plenty of water throughout the day, especially with your meals. This can help prevent dehydration, which can be a side effect of Rybelsus, and support overall digestion and medication absorption.
  • Monitor Blood Sugar Levels: As recommended by your healthcare provider, regularly monitor your blood sugar levels. This can help you track the effectiveness of Rybelsus and make any necessary adjustments to your diet or medication regimen.
  • Be Aware of Potential Side Effects, Allergic Reactions, and Drug Interactions: Pay attention to how your body responds to Rybelsus and report any unusual or persistent side effects to your healthcare provider. Common side effects include abdominal pain, nausea, vomiting, diarrhea, and decreased appetite. In rare individuals, Rybelsus can cause pancreatitis and kidney problems.
  • Follow the Rybelsus Dosage on the Package Insert for Proper Prescribing Information: Remember, do not change your dose of Rybelsus without your doctor’s recommendation.
  • As always, Seek Medical Advice from a healthcare professional for individualized support. Depending on your medical conditions, this medication may or may not be the right fit for you. If you experience any side effects, contact your provider immediately.

Using a CGM with Signos: Real-Time Data, Backed by AI

Signos pairs a real-time glucose biosensor with AI trained on tens of millions of data points to deliver personalized, science-backed guidance for weight management and health. See exactly how your body responds, and take action.

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<p class="pro-tip"><strong>Also Read: </strong><a href=how-long-do-semaglutide-side-effects-last>How Long Do Semaglutide Side Effects Last? A Complete Overview</a>.</p>

Kristen Carli, MS, RD

About the author

Victoria Whittington earned her Bachelor of Science in Food and Nutrition from the University of Alabama and has over 10 years of experience in the health and fitness industry.

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